Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109-2216, USA *Correspondence to:Daniel J. Klionsky, Tel: +1-734-615-6556; Fax: +1-734-647-9702; E-mail: klionsky@umich.edu
Autophagy down-regulates the Wnt signal transduction pathway via targeted degradation of a key signaling protein. This may provide an explanation for autophagy's role in tumor suppression.
